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Easy Creamy Cajun Chicken Spaghetti

Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes
Servings 6 servings
Calories 650
A delightful balance of speed and flavor, this creamy Cajun chicken spaghetti with garlic mozzarella sauce is perfect for quick weeknight dinners.

Ingredients

Main ingredients

  • 1 pound boneless, skinless chicken breasts, cut into bite-sized pieces (Trim any fat and pat the chicken dry so it browns evenly.)
  • 2 tablespoons olive oil (Use a good-quality olive oil for a clean flavor.)
  • 2 tablespoons Cajun seasoning (Taste before adding more. Store-bought is fine or mix your own.)
  • 1 teaspoon smoked paprika (This adds warmth and a gentle smokiness without heat.)
  • 1 pound spaghetti (Use a sturdy spaghetti that holds up to the sauce.)
  • 4 tablespoons butter (Unsalted butter lets you control the final salt level.)
  • 4 cloves garlic, minced (Mash the garlic with the side of your knife for better aroma.)
  • 1/4 cup all-purpose flour (Measure by spooning into the cup for accuracy.)
  • 3 cups whole milk (Whole milk gives the richest, creamiest texture.)
  • 1 cup chicken broth (Use low-sodium broth to adjust salt later.)
  • 8 ounces cream cheese, softened (Let it sit at room temperature for easier melting.)
  • 2 cups shredded mozzarella cheese, divided (Part-skim mozzarella melts well and keeps things lighter.)
  • 1/2 cup grated Parmesan cheese (Freshly grated Parmesan gives the best depth.)
  • Salt and freshly ground black pepper, to taste (Add in small amounts and taste as you go.)
  • optional Red pepper flakes for extra heat (Add a pinch at a time.)

Instructions 

Cooking the Pasta

  • Cook spaghetti according to package directions in salted water until al dente. Drain and set aside.

Preparing the Chicken

  • While pasta cooks, season chicken with Cajun seasoning and smoked paprika.
  • In a large skillet, heat olive oil over medium-high heat. Add chicken and cook until browned and cooked through, about 6–8 minutes. Remove from skillet and set aside.

Making the Sauce

  • In the same skillet, melt butter over medium heat. Add minced garlic and sauté for 1 minute until fragrant.
  • Sprinkle in the flour and whisk continuously for 1–2 minutes to form a roux.
  • Gradually whisk in the milk and chicken broth, stirring constantly to avoid lumps. Bring to a gentle simmer.
  • Add cream cheese and 1 cup of mozzarella, stirring until melted and smooth.
  • Stir in Parmesan cheese and season with salt, pepper, and red pepper flakes if using.

Combining Everything

  • Add cooked chicken back into the sauce and simmer for 2–3 minutes to heat through.
  • Add cooked spaghetti to the skillet and toss to coat in the sauce.
  • Sprinkle remaining 1 cup mozzarella on top, cover, and let sit for 2–3 minutes until cheese melts.
  • Serve hot, garnished with fresh parsley or extra Parmesan if desired.

Notes

Leftovers keep well in the fridge for up to 3 days. Reheat gently to revive creaminess. Avoid freezing with the mozzarella melted on top.
Calories: 650kcal
Course: Dinner, Main Course
Cuisine: American, Italian
Keyword: Cajun Chicken Spaghetti, Comfort Food, Creamy Pasta, Family-Friendly, Quick Dinner